Welcome
Hi ! I am Darshan, a postdoctoral reseracher at the Blue Brain Project-EPFL (BBP), Geneva. I construct and simulate detailed mathematical models of biological neurons and glial cells to hypothesize and predict the causes of unanswered biological phenomena.
Research and Education
Prior to joining BBP, I worked as a Research Associate at the Computational Neurophysiology Lab in Department of Biosciences and Bioengineering (BSBE), Indian institute of Technology (IIT) Bombay.
I also did my M.Tech in Biomedical Engineering and PhD in IIT Bombay. My PhD thesis was supervised by Dr. Rohit Manchanda . My Ph.D. work involved the use of computational tools like NEURON and Scilab to model the peripheral sensory neurons – Dorsal Root Ganglion (DRG) Neurons – supplying the urinary bladder. I also worked on computational model of Satellite Glial Cells, the glial cells surrounding the soma of DRG neurons.
I did my undergraduation in Biomedical Engineering from National Institute of Technology, Raipur. I worked in a market research company called MarketRx (now part of Cognizant) training as a market research analyst.
Publications
Journal- D. Mandge and R. Manchanda, "A biophysically detailed computational model of urinary bladder small DRG neuron soma" PLOS Computational Biology, 14(7): e1006293. 2018. (Model Links: ModelDB, GitHub). This paper was awarded one of the Best Paper Award by Dept.of Biosciences and Bioengineering, IIT Bombay. The article was featured on the PLOS Computational Biology website (image) and twitter page. A layman's description of important results of the paper can be found on the Reseach Matters webpage.
- D. Mandge, P.R. Shukla, A. Bhatnagar and R. Manchanda, (2019, July)."Computational Model for Cross-Depolarization in DRG Neurons via Satellite Glial Cells using [K]o: Role of Kir4.1 Channels and Extracellular Leakage". In Engineering in Medicine and Biology Society (EMBC) , 2019 41st Annual International Conference of the IEEE, Berlin, 2019, pp.2320-2023
- D. Mandge, A. Bhatnagar and R. Manchanda, “Computational Model for Intercellular Communication between DRG Neurons via Satellite Glial Cells using ATP.” 2017 8th International IEEE/EMBS Conference on Neural Engineering (NER), Shanghai, 2017.
- S. Aruljothi, D. Mandge, and R. Manchanda, “A Biophysical Model of Heat Sensitivity in Nociceptive C-Fiber Neurons.” 2017 8th International IEEE/EMBS Conference on Neural Engineering (NER), Shanghai, 2017.
- D. Mandge and R. Manchanda, "Computational studies on bladder small dorsal root ganglion neurons: Modelling BK channels." 2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), Milan, 2015, pp. 5376-5379
Presentation and Talks
- List of some useful links in computational Neuroscience
- "An Introductory Talk on Computational Neuroscience" at BioTech Club, IIT Bombay (March 2016)
- Talk on "Network Level Models in Computational Neuroscience" for students of Sophia College For Women, IIT Bombay (March 2014)
- "Lecture on the Hodgkin-Huxley Model" for a short course on Mathematical Modelling for Neurophysiology using Open Source Softwares at Govt. Engineering College, Chandrapur, Maharashtra (February 2014)
- Interactive tools to learn Nernst and GHK equations
- ModelDb entry and NEURON-python code for Mandge and Manchanda 2018
- Ion Concentration Clamp in NEURON
- Multiple Successive Voltage Clamps in NEURON
- Ramp Current Clamp in NEURON
Codes
- (Github Profile)